ISSN: 2149-2247 | E-ISSN: 2149-2549
Erciyes Medical Journal Plasma Exchange in the Treatment of A Child with West Nile Virus Encephalitis: A Case Report [Erciyes Med J]
Erciyes Med J. 2022; 44(4): 430-433 | DOI: 10.14744/etd.2021.96606

Plasma Exchange in the Treatment of A Child with West Nile Virus Encephalitis: A Case Report

Yasemin Özkale1, Murat Özkale2, Özgür Ceylan3, Ilknur Erol4
1Department of Pediatrics, Başkent University Faculty of Medicine, Adana, Türkiye
2Department of Pediatric Intensive Care, Başkent University Faculty of Medicine, Adana, Türkiye
3Department of Pediatric Infection, Başkent University Faculty of Medicine, Adana, Türkiye
4Department of Pediatric Neurology, Başkent University Faculty of Medicine, Ankara, Türkiye

Background: West Nile virus (WNV) is a member of the Japanese encephalitis antigenic complex of the family Flaviviridae that can cause a wide range of clinical symptoms, from asymptomatic disease to severe meningitis, encephalitis flaccid paral-ysis, and death. In immunocompetent children, WNV infection is usually benign and self-limiting. However, this virus is also associated with severe neurological disease in some patients, especially those who are older, have a chronic disease, have undergone organ transplantation, or are immunocompromised.
Case Report: A 12-year-old boy with selective immunoglobulin A-deficiency (SIgAD) and refractory seizures due to WNV encephalitis (WNE) was successfully treated with therapeutic plasma exchange (TPE) in conjunction with other immunomod-ulatory therapies.
Conclusion: WNV can progress like autoimmune encephalitis. TPE appears to be safe and effective for treating children with WNE. To our knowledge, this report is the first of a child with WNV infection and SIgAD.

Keywords: Children, epilepsy, plasma exchange, treatment, West Nile virus.

Yasemin Özkale, Murat Özkale, Özgür Ceylan, Ilknur Erol. Plasma Exchange in the Treatment of A Child with West Nile Virus Encephalitis: A Case Report. Erciyes Med J. 2022; 44(4): 430-433

Corresponding Author: Yasemin Özkale, Türkiye
Manuscript Language: English
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