ISSN: 2149-2247 | E-ISSN: 2149-2549
Erciyes Medical Journal The War Against the Resistance of Acinetobacter Baumannii: A Meta-analysis of Findings in Türkiye [Erciyes Med J]
Erciyes Med J. 2022; 44(5): 447-454 | DOI: 10.14744/etd.2022.94770

The War Against the Resistance of Acinetobacter Baumannii: A Meta-analysis of Findings in Türkiye

İhsan Hakkı Çiftçi1, İmdat Kilbaş2, Elmas Pınar Kahraman Kılbaş3
1Department of Microbiology, Sakarya University Faculty of Medicine, Sakarya, Türkiye
2İstanbul University, Institute of Health Sciences, Doctoral Program in Medical Microbiology, İstanbul, Türkiye
3Department of Medical Laboratory Techniques, Fenerbahçe University, Health Services Vocational School, İstanbul, Türkiye

Bacterial resistance to antibiotics continues to be a significant challenge to the global health system. This study was designed to examine changes in the antibiotic resistance of Acinetobacter baumannii (A. baumannii) strains isolated from various clinical samples taken between 2005 and 2020 and to support the development of new antibiotics policies for empirical treatment of multidrug-resistant isolates in Türkiye. This meta-analysis included a data search phase, determination of eligibility criteria, quali-tative analysis of the studies selected, data extraction, and statistical analyses. All of the data were analyzed according to the Pre-ferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. According to Clinical and Laboratory Standards Institute and/or European Committee on Antimicrobial Susceptibility Testing standards and a random effects model, the breakpoint estimate of A. baumannii strain resistance in Türkiye for ampicillin-sulbactam, ceftazidime, imipenem, mero-penem, gentamicin, amikacin, ciprofloxacin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, netilmicin, colistin, and tigecycline was 90.7%, 92.1%, 86.8%, 87.3%, 72.6%, 63.7%, 88%, 91.2%, 76.7%, 27.1%, 7.9%, and 18.5%, respectively. The reported rates of A. baumannii resistance from different regions demonstrated heterogeneity. Unfortunately, the use of standard antibiotics is unlikely to provide effective therapy throughout Türkiye. New therapy options and protocols are needed.

Keywords: Acinetobacter baumannii, antibiotic, infectious, resistance, treatment.

İhsan Hakkı Çiftçi, İmdat Kilbaş, Elmas Pınar Kahraman Kılbaş. The War Against the Resistance of Acinetobacter Baumannii: A Meta-analysis of Findings in Türkiye. Erciyes Med J. 2022; 44(5): 447-454

Corresponding Author: İmdat Kilbaş, Türkiye
Manuscript Language: English
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