Objective: Concerns are growing about the prevalence of liver cancer as one of the most common health-threatening cancers due to the numerous risk factors for this type of cancer such as hepatitis, obesity, diabetes and fatty liver. This review article was done to investigate the protective role of probiotics and their metabolites against liver cancer, where probiotics showed various useful effects for treatment of disease especially cancer.
Materials and Methods: For this study, searches were carried out using keywords including probiotic, Bacteria, Lactobacillus, Bifidobacterium, Liver Cancer and Hepatocellular Carcinoma from reliable databases such as Google Scholar, PubMed, Science Direct, and Wiley.
Results: This review revealed that, where products of probiotic bacteria had also therapeutic effects such as OK-432, Nisin, Bovicin HC5 (as important products), probiotic bacteria of the genus Lactobacillus and Bifidobacterium such as Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus strains were the most useful probiotic bacteira against liver cancer.
Conclusion: The use of probiotics due to their natural source and their secretory metabolites can be a good way to develop new therapies for various diseasesm with this systematic review showing that probiotics have shown therapeutic effects on liver cancer by having a wide range of properties such as anti-inflammatory and anti-apoptotic properties.