ISSN: 2149-2247 | E-ISSN: 2149-2549
Erciyes Medical Journal Review of the Effects of Probiotics and Their Metabolites in the Treatment of Liver Cancer: An Update on Probiotics as a New Treatment [Erciyes Med J]
Erciyes Med J. 2023; 45(1): 8-18 | DOI: 10.14744/etd.2022.25477

Review of the Effects of Probiotics and Their Metabolites in the Treatment of Liver Cancer: An Update on Probiotics as a New Treatment

Sheyda Bouzari1, Ronak Bakhtiari2, Hatef Ajoudanifar1, Seyed Ataollah Sadat Shandiz3
1Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Objective: Concerns are growing about the prevalence of liver cancer as one of the most common health-threatening cancers due to the numerous risk factors for this type of cancer such as hepatitis, obesity, diabetes and fatty liver. This review article was done to investigate the protective role of probiotics and their metabolites against liver cancer, where probiotics showed various useful effects for treatment of disease especially cancer.
Materials and Methods: For this study, searches were carried out using keywords including probiotic, Bacteria, Lactobacillus, Bifidobacterium, Liver Cancer and Hepatocellular Carcinoma from reliable databases such as Google Scholar, PubMed, Science Direct, and Wiley.
Results: This review revealed that, where products of probiotic bacteria had also therapeutic effects such as OK-432, Nisin, Bovicin HC5 (as important products), probiotic bacteria of the genus Lactobacillus and Bifidobacterium such as Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus strains were the most useful probiotic bacteira against liver cancer.
Conclusion: The use of probiotics due to their natural source and their secretory metabolites can be a good way to develop new therapies for various diseasesm with this systematic review showing that probiotics have shown therapeutic effects on liver cancer by having a wide range of properties such as anti-inflammatory and anti-apoptotic properties.

Keywords: Probiotics, bacteria, neoplasms, liver neoplasms, carcinoma, hepatocellular.

Sheyda Bouzari, Ronak Bakhtiari, Hatef Ajoudanifar, Seyed Ataollah Sadat Shandiz. Review of the Effects of Probiotics and Their Metabolites in the Treatment of Liver Cancer: An Update on Probiotics as a New Treatment. Erciyes Med J. 2023; 45(1): 8-18

Corresponding Author: Ronak Bakhtiari, Iran
Manuscript Language: English
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