ISSN: 2149-2247 | E-ISSN: 2149-2549
Volume : 43 Issue : 4 Year : 2021
LC3 and Beclin-1 as Markers of Autophagic Activity in Breast Cancer [Erciyes Med J]
Erciyes Med J. 2021; 43(4): 333-336 | DOI: 10.14744/etd.2020.99997

LC3 and Beclin-1 as Markers of Autophagic Activity in Breast Cancer

Nursultan Nurdinov, Venhar Çınar, Ahsen Güler, Sevda Gökçe Yılmaz, Nesrin Delibaşı, Zuhal Hamurcu
Betül-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri, Turkey; Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Autophagy is a catabolic pathway meaning “self-eating” that facilitates nutrient recycling from damaged and aged organelles and other impaired cellular components through lysosomal degradation. Regulation of this process has been associated with the development of cancer. It can play different roles at different tumors and developmental stages of tumors. In breast cancer, similarly, autophagy functions as a mechanism promoting survival or leading to death. Whereas, it is very important to define the role of autophagy as an effective treatment strategy in breast cancer cells. Therefore, in this review, the role of inhibited autophagy is discussed with specific RNAs targeting Beclin-1 and LC3 genes in breast cancer.

Keywords: Autophagy, beclin-1, breast cancer, LC3, siRNA.

Nursultan Nurdinov, Venhar Çınar, Ahsen Güler, Sevda Gökçe Yılmaz, Nesrin Delibaşı, Zuhal Hamurcu. LC3 and Beclin-1 as Markers of Autophagic Activity in Breast Cancer. Erciyes Med J. 2021; 43(4): 333-336

Corresponding Author: Zuhal Hamurcu, Türkiye
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