ISSN: 2149-2247 | E-ISSN: 2149-2549
Volume : 44 Issue : 3 Year : 2022
Evaluation of Monocyte to High-Density Lipoprotein Cholesterol and Neutrophil to High-Density Lipoprotein Cholesterol Ratios as Indicators of Inflammation in Patients with Celiac Disease [Erciyes Med J]
Erciyes Med J. 2022; 44(3): 274-278 | DOI: 10.14744/etd.2021.99975

Evaluation of Monocyte to High-Density Lipoprotein Cholesterol and Neutrophil to High-Density Lipoprotein Cholesterol Ratios as Indicators of Inflammation in Patients with Celiac Disease

Tolga Duzenli1, Derya Köseoğlu2, Hüseyin Köseoğlu1
1Department of Gastroenterology, Hitit University Erol Olçok Training and Research Hospital, Çorum, Turkey
2Department of Endocrinology and Metabolism, Hitit University Erol Olçok Training and Research Hospital, Çorum, Turkey

Objective: Celiac disease (CD) is an autoimmune disease with multisystemic manifestations that may be consequences of autoimmunity, inflammation, or malabsorption. The monocyte to high-density lipoprotein cholesterol ratio (MHR) and the neutrophil to high-density lipoprotein cholesterol ratio (NHR) are recent markers of inflammation. The aim of the present study was to analyze the relationship between the MHR, NHR, and CD and to examine whether these measures might be used as inflammatory markers in CD.
Materials and Methods: This cross-sectional, retrospective study included 153 participants. The data of 50 patients with CD and 103 healthy individuals enrolled as a control group were evaluated. Receiver operating characteristic (ROC) analysis and the corresponding area under the curve (AUC) calculation were performed to assess the discriminatory ability of the MHR and the NHR.
Results: The MHR and the NHR were both high in the study participants with CD (p<0.001). ROC analysis revealed an AUC value of 0.725 (95% confidence interval [CI]: 0.639–0.811) for the MHR and 0.695 (95% CI: 0.598–0.792) for the NHR (p<0.001). The cut-off value for MHR was 9.312 (sensitivity: 76.7%, specificity: 65%) and 77.79 for NHR (sensitivity: 67.4%, specificity: 65%). No statistically significant correlation was seen between the MHR and NHR values and the modified Marsh scores of the patients with CD.
Conclusion: The current study is believed to be the first in the literature to explore and demonstrate that the MHR and the NHR may be indicators in patients with CD. The MHR and the NHR may be promising diagnostic markers for CD.

Keywords: Celiac disease, high-density lipoprotein cholesterol, inflammation, monocyte, neutrophil.

Tolga Duzenli, Derya Köseoğlu, Hüseyin Köseoğlu. Evaluation of Monocyte to High-Density Lipoprotein Cholesterol and Neutrophil to High-Density Lipoprotein Cholesterol Ratios as Indicators of Inflammation in Patients with Celiac Disease. Erciyes Med J. 2022; 44(3): 274-278

Corresponding Author: Tolga Duzenli, Türkiye
Manuscript Language: English
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