ISSN: 2149-2247 | E-ISSN: 2149-2549
Volume : 43 Issue : 6 Year : 2021
The Association Between Refeeding Hypophosphatemia and Serum Appetite-Regulating Hormone Levels in Critically Ill Patients: A Prospective, Observational, Single-Center Pilot Study [Erciyes Med J]
Erciyes Med J. 2021; 43(2): 146-151 | DOI: 10.14744/etd.2020.94580

The Association Between Refeeding Hypophosphatemia and Serum Appetite-Regulating Hormone Levels in Critically Ill Patients: A Prospective, Observational, Single-Center Pilot Study

Ender Doğan1, Kürşat Gündoğan2, Şahin Temel2, Serap Şahin3, Nurhayat Tuğra Özer3, Gülşah Güneş Şahin3, Sabahattin Muhtaroğlu4, Murat Sungur2, Muhammet Güven5
1Department of Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey
2Division of Medical Intensive Care, Department of Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey
3Department of Clinical Nutrition, Institute of Health Sciences, Erciyes University, Kayseri, Turkey
4Department of Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Turkey
5Department of Internal Medicine, Lokman Hekim University Faculty of Medicine, Ankara, Turkey

Objective: Refeeding hypophosphatemia (RH) is common in critically ill patients and is associated with high morbidity and mortality, but the influence on appetite-regulating hormones is unknown. This study aimed to determine the association between serum levels of phosphorus and specific appetite-regulating hormones in critically ill patients.
Materials and Methods: This study was performed prospectively in patients admitted to the intensive care unit (ICU). The study included patients aged ≥18 years who were admitted to the ICU and feeding at least 72 hours (h). Serum was obtained at baseline, 24 h, and 72 h later for concentrations of leptin, adiponectin, ghrelin, resistin, insulin-like growth factor 1 (IGF-1), and glucagon-like peptide 1 (GLP-1). Phosphorus levels were accepted at ≤2.4 mg/dL for RH.
Results: Of the 26 cases, 17 (65%) were male. The baseline phosphorus levels at baseline, 24 h, and 72 h were 3.58±0.94 mg/dL, 2.61±1.05 mg/dL, and 2.91±0.76 mg/dL, respectively. RH rate was developed 24 h, 72 h, and over time in 38%, 15%, and 42% patients, respectively. Adiponectin levels at 24 h were significantly different between patients who developed RH and those who did not develop RH. A positive correlation was observed between 24 h serum adiponectin level and 24 h phosphorus level. A positive correlation was found between baseline serum ghrelin level and baseline phosphorus level. No significant difference was found between RH and insulin, leptin, ghrelin, resistin, IGF-1, and GLP-1 at baseline, 24 h, and 72 h.
Conclusion: RH was found to be of high ratio in critically ill patients. Adiponectin level was found to be high at 24 h in patients with RH.

Keywords: Refeeding hypophosphatemia, appetite-regulating hormones, enteral nutrition, parenteral nutrition, critically ill patients

Ender Doğan, Kürşat Gündoğan, Şahin Temel, Serap Şahin, Nurhayat Tuğra Özer, Gülşah Güneş Şahin, Sabahattin Muhtaroğlu, Murat Sungur, Muhammet Güven. The Association Between Refeeding Hypophosphatemia and Serum Appetite-Regulating Hormone Levels in Critically Ill Patients: A Prospective, Observational, Single-Center Pilot Study. Erciyes Med J. 2021; 43(2): 146-151

Corresponding Author: Kürşat Gündoğan, Türkiye
Manuscript Language: English
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