Introduction: Miller Fisher Syndrome is a variant of Guillain-Barre Syndrome, classically characterized by triad of ataxia, areflexia and ophthalmoplegia. However, many conditions can masquerade the presentation of Miller Fisher Syndrome, potentially leading to grave consequences due to delayed diagnosis or even misdiagnosis.
Case report: Presently described is a case of Miller Fisher Syndrome mimicking acute sphenoid sinusitis with intracranial complication, in an otherwise healthy 19-year-old gentleman. Nevertheless, accurate diagnosis with prompt treatment led to full clinical recovery of our patient.
Conclusion: Sphenoid sinusitis warrants great vigilance and thorough neurological examination due to its proximity to structures such as cavernous sinus and its associated cranial nerves. This case highlights its potential to mask more devastating condition like Miller Fisher Syndrome and successful role of medical management without need for sphenoidotomy