ISSN: 2149-2247 | E-ISSN: 2149-2549
Volume : 44 Issue : 4 Year : 2022
Evaluation of Serum Growth Arrest-Specific 6/ Soluble AXL Levels in Type 2 Diabetes Mellitus [Erciyes Med J]
Erciyes Med J. 2022; 44(4): 411-415 | DOI: 10.14744/etd.2022.45403

Evaluation of Serum Growth Arrest-Specific 6/ Soluble AXL Levels in Type 2 Diabetes Mellitus

Merve Özel1, Gülden Başkol1, Amir Hossein Abedi2, Yasemin Atıcı3, Hatice Saraçoğlu1, Neslihan Sungur1, Fahri Bayram4
1Department of Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Türkiye
2Department of Internal Medicine Medistanbul Hospital, İstanbul, Türkiye
3Department of Biochemistry, Lokman Hekim University Faculty of Medicine, Ankara, Türkiye
4Department of Endocrinology and Metabolism, Erciyes University Faculty of Medicine, Kayseri, Türkiye

Objective: The aim of this study was to investigate an association between serum growth arrest-specific 6 (Gas6), AXL, and soluble AXL (sAXL) levels and the glycosylated hemoglobin (HbA1c) and estimated glomerular filtration rate (eGFR) in diabetic patients.
Materials and Methods: This study included type 2 diabetes mellitus (T2DM) patients of a department of endocrinology and healthy individuals. The HbA1c and creatinine levels of all of the participants were evaluated using autoanalyzers and the eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration formula. The Gas6, AXL, and sAXL serum protein concentrations were analyzed using enzyme-linked immunosorbent assays.
Results: The study group consisted of 51 patients (34 females and 17 males) diagnosed with T2DM and 17 healthy controls (9 females and 8 males). The Gas6, AXL, and sAXL concentrations were significantly lower in the patient group (p<0.05). There was a significant positive correlation between the Gas6, AXL, and sAXL parameters in both groups. The eGFR was negatively correlated with the Gas6 and sAXL levels in the patient group (r=-0.285, p<0.047; r=-0.311, p<0.028, respec-tively), while there was no correlation observed in the control group.
Conclusion: Gas6, AXL, and sAXL have an important role in the pathogenesis of T2DM. Gas6 and sAXL appear to have a potentially predictive value for diabetic nephropathy. Further clinical studies are necessary to clarify this mechanism.

Keywords: AXL, estimated glomerular filtration rate, glycosylated hemoglobin, serum growth-arrest specific 6, soluble AXL

Merve Özel, Gülden Başkol, Amir Hossein Abedi, Yasemin Atıcı, Hatice Saraçoğlu, Neslihan Sungur, Fahri Bayram. Evaluation of Serum Growth Arrest-Specific 6/ Soluble AXL Levels in Type 2 Diabetes Mellitus. Erciyes Med J. 2022; 44(4): 411-415

Corresponding Author: Merve Özel, Türkiye
Manuscript Language: English
LookUs & Online Makale