ISSN: 2149-2247 | E-ISSN: 2149-2549
Volume : 45 Issue : 1 Year : 2023
The Effect of Transcatheter Ventricular Septal Defect Closure on Children’s Appetite, Hormones, and Growth [Erciyes Med J]
Erciyes Med J. Ahead of Print: EMJ-41848 | DOI: 10.14744/etd.2022.41848

The Effect of Transcatheter Ventricular Septal Defect Closure on Children’s Appetite, Hormones, and Growth

Onur Tasci1, Ozge Pamukcu1, Nazmi Narin1, Didem Barlak Keti2, Suleyman Sunkak1, Çağdaş Vural1, Nihal Hatipoglu3, Ali Baykan1
1Department of Pediatric Cardiology, Erciyes University Faculty of Medicine, Kayseri, Türkiye
2Department of Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Türkiye
3Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine, Kayseri, Türkiye

Objective: Children with congenital heart disease are at risk for malnutrition. The aim of this study is to investigate the changes in appetite, nutritional hormones, and anthropometric measurements of patients before and after the transcatheter closure of ventricular septal defect.
Materials and Methods: Twenty patients whose defect was closed percutaneously and 26 children as healthy control group were included in the study. The anthropometric evaluation, symptoms, and blood tests of patient group were enrolled at initial and follow-up (1st and 6th month visit).
Results: The median age of patient and control group was 27 and 29.5 months, respectively. Lack of appetite, inadequate weight gain, and fatigue were higher in the patient group at initial visit (p=0.027, p=0.029, and p=0.033, respectively). At 1st month after closure, the rate of decrease in lack of appetite, inadequate weight gain, and fatigue were statistically significant (p=0.016, p=0.031, and p=0.031, respectively). After closure, increasing body mass index, its z score, and mid-upper arm circumference were statistically significant at 1st month (p=0.008, p=0.018, and p=0.018, respectively). Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and their z scores were increased compared to the initial values at 1st month (p=0.001, p=0.033, p=0.002, and p=0.048, respectively). Ghrelin levels showed a linear decrease; leptin levels showed a linear increase for 6 months.
Conclusion: Children with ventricular septal defect are under the risk of malnutrition. One of the goals of our treatment plan for these children should be the prevention of malnutrition; therefore, the timing of interventional therapy should be before malnutrition develops

Keywords: Children, ghrelin, growth, leptin, transcatheter, ventricular septal defect.



Corresponding Author: Onur Tasci, Türkiye
Manuscript Language: English
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