ISSN: 2149-2247 | E-ISSN: 2149-2549
Volume : 44 Issue : 6 Year : 2022
Evaluation of Subclinical Inflammation in Children with Premature Adrenarche [Erciyes Med J]
Erciyes Med J. 2022; 44(6): 603-607 | DOI: 10.14744/etd.2022.39699

Evaluation of Subclinical Inflammation in Children with Premature Adrenarche

Gözde Köylü1, Nurullah Çelik2, Halef Okan Doğan3
1Department of Pediatrics, Cumhuriyet University Faculty of Medicine, Sivas, Türkiye
2Division of Pediatric Edocrinology, Department of Pediatrics, Cumhuriyet University Faculty of Medicine, Sivas, Türkiye
3Department of Biochemistry, Cumhuriyet University Faculty of Medicine, Sivas, Türkiye

Objective: The objectives of this study were to compare the serum inflammatory markers, interleukin-6 (IL-6), highly sensi-tive C-reactive protein (hs-CRP), and fetuin-A, in patients with premature adrenarche (PA) and the control group.
Materials and Methods: This single-center cross-sectional study included 85 non-obese and pre-pubertal children. After 8–12 h of fasting, blood glucose, HDL, LDL, triglyceride, cholesterol, insulin, dehydroepiandrosterone sulfate, total testosterone, 17-OH PG, IL-6, hs-CRP, and Fetuin-A levels were measured and compared in a convenience sample of PA (n=35) and a healthy volunteers of control (n=50) group.
Results: The mean age (7.34±0.62 years vs. 7.09±0.77 years, respectively) and sex (82% girl vs. 80% girl, respectively) of the PA and control groups were similar (p>0.05). Fasting insulin levels (10.9±6.21 Uu/mL vs. 7.4±5.9 Uu/mL; p<0.001), HOMA-IR (2.06±0.63 vs. 1.36±1.00; p=0.017), FGIR (11.31±5.60 vs. 16.46±8.52; p=0.004), and QUICKI (0.35±0.02 vs. 0.37±0.03; p<0.001) levels were different in PA and control groups. IL-6 level higher in PA group than controls [2.7 (3.30) pg/mL vs. 3.02 (1.31) pg/mL, p=0.035], while plasma Fetuin-A [522.02 (715.86) mg/L; 519.4 (945.97) mg/L, p=0.434] and hs-CRP [0.73 (1.02) mg/dL; 1.0 (1.12) mg/dL, p=0.439] levels were similar. IL-6 cutoff value for PA was calculated as 2.06 with 72.7% sensitivity and 48.8% specificity for all study groups (AUC=0.641, p=0.036).
Conclusion: The high IL-6 levels may be an indicator of chronic subclinical inflammation in PA cases. These children should be followed closely in terms of metabolic disorders.

Keywords: Fetuin-A, highly sensitive c-reactive protein, inflammation, interleukin-6, premature adrenarche.

Gözde Köylü, Nurullah Çelik, Halef Okan Doğan. Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. Erciyes Med J. 2022; 44(6): 603-607

Corresponding Author: Nurullah Çelik, Türkiye
Manuscript Language: English
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