ISSN: 2149-2247 | E-ISSN: 2149-2549
Volume : 44 Issue : 4 Year : 2022
Rare Presentation of a Common Hematological Malignancy [Erciyes Med J]
Erciyes Med J. 2022; 44(4): 434-436 | DOI: 10.14744/etd.2021.36048

Rare Presentation of a Common Hematological Malignancy

Anirudh J Shetty1, Sujit Janardhanan2, Rimesh Pal1
1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2Department of Radiodiagnosis and Imaging, MVJ Medical College and Research, Bangalore, India

Background: Metastatic spinal cord compression (MSCC) is a well-recognized complication of underlying malignancies; however, MSCC is rarely seen in acute leukemia.
Case Report: A 24-year-old female presented with low backache, right lower limb radicular pain, right foot drop, and loss of bladder sensation, suggestive of cauda conus syndrome. Magnetic resonance images revealed an enhanced pre-/paraver-tebral lesion extending from the L5-S3 level with destruction of the vertebral body and intraspinal infiltration. A peripheral blood smear revealed atypical cells, which bone marrow analysis confirmed to be vacuolated myeloblasts. A diagnosis was made of acute myeloid leukemia (AML) type M4 with spinal myeloid sarcoma leading to cord compression. A cytarabine and doxorubicin-based chemotherapy regimen was initiated. Her symptoms improved after 2 cycles, however, she developed febrile neutropenia after 4 cycles of treatment and died.
Conclusion: MSCC, although rare, can be a presenting complaint of AML resulting from cord compression due to spinal myeloid sarcoma.

Keywords: Acute leukemia, acute myeloid leukemia, metastatic spinal cord compression, myeloid sarcoma.

Anirudh J Shetty, Sujit Janardhanan, Rimesh Pal. Rare Presentation of a Common Hematological Malignancy. Erciyes Med J. 2022; 44(4): 434-436

Corresponding Author: Anirudh J Shetty, India
Manuscript Language: English
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