ISSN 2149-2247 | E-ISSN 2149-2549
Original Article
Predictive Significance of Preoperative Neutrophil to Lymphocyte Ratio versus Platelet to Lymphocyte Ratio for Gleason score in Prostate Cancer Patients
1 Department of Urology, Yuksek İhtisas University Faculty of Medicine, Koru Ankara Hospital, Ankara, Turkey  
Erciyes Med J ; : -
DOI: 10.5152/etd.2018.18107
Key Words: Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, prostate carcinoma, Gleason score
Abstract

Objective: Inflammation has critical role in development and progression of cancer. Neutrophil to lymphocyte ratio (NLR) and Platelet to lymphocyte ratio (PLR) are easily accessible basic inflammatory parameters. Here, we aimed to analyze the association between NLR, PLR and Gleason score of prostate cancer that is main parameter for prognosis of prostate cancer


Materials and Methods
: A total 173 prostate cancer patients (mean age 63±6.2 years) who were performed radical prostatectomy included in to this retrospective study. The NLR and PLR were derived from the complete blood cell count results at preoperative period. Patients were divided in to two groups as low-grade prostate cancer [Gleason score ≤7 (3-4)] and high-grade [Gleason score≥ 7(4+3)]. Logistic regression analysis was performed to determine the association.


Results
: Univariate logistic regression analysis showed that Ln PSA [1.83, 95% CI (1.01, 3.3) p=0.04], Lnlymphocyte [0.38, 95% CI (0.15, 0.94) p=0.03] and LnNLR [ 1.9, 95%CI 1.9 (1.13, 3.38) p=0.01] levels were significantly associated with high-grade Gleason score. However, lnPLR levels revealed association with marginal statistically significance [2.06, 95 % CI (0.95, 4.4) p=0.06].  In multiple analyses, after adjusting the analysis for age, Ln NLR [1.96, 95% CI (1.12, 3.42) p=0.01 and Ln lymphocyte levels [ 0.38, 95% CI (0.15, 0.97) p= 0.04] were still statistically significantly associated with high-grade prostate cancer


Conclusion
:  Higher NLR levels were significantly associated with high-grade prostate cancer. However, PLR levels were not significant predictor for higher Gleason scores.


Cite this article as
: Ergin G, Köprü B, Kıraç M, Kibar Y, Biri H.  Predictive Significance of Preoperative Neutrophil to Lymphocyte Ratio versus Platelet to Lymphocyte Ratio for Gleason score in Prostate Cancer Patients  Erciyes Med J 2018; DOI: 10.5152/etd.2018.18107

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