ISSN 2149-2247 | E-ISSN 2149-2549
Original Article
Evaluation of metabolic risk markers: Calcium/magnesium ratio, lipoproteins and insulin resistance in patients with obstructive sleep apnea syndrome
1 Clinical Biochemistry, Kayseri Training and Research hospital Chest Diseases, Kayseri Training and Research hospital  
Erciyes Med J ; : -
DOI: 10.5152/etd.2017.0109
Key Words: Calcium to magnesium ratio; insulin resistance; lipoproteins; obstructive sleep apnea syndrome; male patients
Abstract

Objectives: Obstructive sleep apnea syndrome (OSAS) is described as repetitive apnea episodes that lead to inflammation, ischemia/hypoxia and may also have effects on mineral and metabolic markers. We aimed to examine the relationships between calcium (Ca), magnesium (Mg), Ca/Mg ratio, insulin sensitivity-resistance markers (glucose, insulin, HOMA-IR), cardiovascular markers (lipids,lipoproteins), their relationships with each other, and to find out the possible influence of Ca/Mg ratio on metabolic markers in OSAS.


Material and Methods: Male patients' metabolic markers and mineral levels were compared with those of control subjects.


Results: In OSAS group fasting glucose and insulin levels were statistically significantly higher (P= 0.004 and 0.003, respectively) and fasting glucose levels were correlated with Ca, Mg and Ca/Mg ratios (0.012, 0.001 and 0.000, respectively). Calcium levels were correlated with HOMA-IR (P= 0.015). Severe OSAS patients had statistically significantly higher Ca/Mg ratios (P = 0.017) and HOMA-IR levels (P = 0.003) than mild/moderate group but correlation between Ca/Mg ratio and HOMA-IR wasn't statistically significant.


Conclusion: Mg and Ca levels were appear related to insulin resistance markers in patients. Severe OSAS patients had statistically higher Ca/Mg ratios than mild/moderate group's so they might represent a risk group with respect to diabetes.


Cite this article as: Çakır I, Uluhan M. Evaulation of metabolic risk markers: Calcium to magnesium ratio, lipoproteins and insulin resistance in male patients with obstructive sleep apnea syndrome. Erciyes Med J 2018; DOI: 10.5152/etd.2017.0109

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