ISSN 2149-2247 | E-ISSN 2149-2549
Original Article
Adipokine levels and perilipin gene polymorphisms in obese Turkish adolescents with non-alcoholic fatty liver disease
1 Department of Pediatric Gastroenterology, Hepatology and Nutrition, Adnan Menderes University Faculty of Medicine, Aydın, Turkey  
2 Department of Pediatric Gastroenterology, Hepatology and Nutrition, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey  
3 Department of Medical Biology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey  
4 Department of Biochemistry, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey  
5 Research Laboratory, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey  
Erciyes Med J ; : -
DOI: 10.5152/etd.2018.0010
Key Words: Adolescent, Non-alcoholic fatty liver disease, Perilipin polymorphism, Adipokines, Obesity
Abstract

 

Objective: The aim of the present study was to evaluate the relationship between adipokines and perilipin (PLIN) polymorphisms with non-alcoholic fatty liver disease (NAFLD).

 

Materials and Methods: Obese Turkish adolescents were assessed in the study. The patients were divided into two groups: obese (NAFLD and non-NAFLD) and non-obese. Serum leptin, adiponectin, resistin, and ghrelin levels and PLIN gene analysis (PLIN 1, 4, and 6) were studied in all patients and healthy control group. Data obtained were compared with those of healthy control group.

 

Results: Overall, 83 obese adolescents with NAFLD, 123 obese adolescents with normal liver, and 102 healthy non-obese adolescents as the control group were evaluated. No significant difference was observed in terms of serum adipokine (leptin, adiponectin, resistin, and ghrelin) levels in patients with NAFLD and non-NAFLD obese adolescents. The incidence of major alleles of PLIN 6 genotype in obese adolescents without NAFLD was slightly higher than that in the control group (p = 0.06). PLIN 6 minor allele incidence was significantly lower (p = 0.01), and PLIN 4 major allele frequency in patients with NAFLD was slightly lower than those in the control group (p = 0.05).

 

Conclusion: These findings suggested that no adipokine role was determined in the development of fatty liver in obese adolescents. The low rate in PLIN 6 minor allele can be a risk factor for NAFLD in adolescents.

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