ISSN 2149-2247 | E-ISSN 2149-2549
1 Biophysics Department, Faculty of Science, Cairo University  
2 Cairo University Hospital  
Erciyes Med J ; : -

Abstract

Objective: In dynamic renal scans, 99mTc-diethylenetriamine pentaacetic acid (DTPA) is copiously used and yields information about the renal blood-flow and the excretory capacity. 99mTc-dimercaptosuccinic acid (DMSA) is utilized for static renal imaging and can likewise uncover the renal cortical structure. This work was intended to assess whether DMSA can be declared as a radiopharmaceutical in dynamic renal scans or not. It scopes also on comparing the outcomes procured from DMSA with those obtained with DTPA examinations.


Methods
: A comparison of the information gained from the renograms of 47 subjects (normal subjects and abnormal renal function patients having: obstructive nephropathy, bilateral nephropathy, hydro-nephrosis, reduced or non-function kidney and/or atrophic kidney) that had 99mTc-DMSA and 99mTc-DTPA dynamic scintigraphies utilizing the same protocol.


Results
: A strong positive correlation had come in view on assessing of the left kidney, right kidney and the total glomerular filtration rate (GFR) from 99mTc-DTPA and 99mTc-DMSA renograms. In addition, estimation of the time of the peak height from99mTc-DTPA and 99mTc-DMSA renograms for the right and left kidneys demonstrated non-significant varieties and strong positive correlation for both the normal subjects and patients with kidney abnormalities.


Conclusion
: In the light of the outcomes gained from the present investigation, it could be prescribed that 99mTc-DMSA could be favorably replace99mTc- DTPA in dynamic renograms in the case of the renal conditions that had been examined in the present work. As scheduled, this will be cash and time saving, and will bring down the radiation dose to the patients. Also , the same qualities of results are accomplished with both radiopharmaceuticals in normal subjects and abnormal renal function patients.


Cite this article as
: Fahmy HM, Yassin HM, Muhammed IM, Mohamed SE, Hassan SS. Evaluation of the efficiency of 99mTc-DMSA as a radiopharmaceutical in dynamic renal scans. Erciyes Med J 2018; DOI: 10.5152/etd.2018.0014

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