ISSN 2149-2247 | E-ISSN 2149-2549
Original Investigation
Morinda Citrifolia (Noni) and Low Dose Aspirin Prevent Apoptotic Cell Death and Oxidative Stress on Isoproterenol Induced Myocardial Infarction in Rats
1 Department of Biochemistry, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey  
Erciyes Med J 2017; 39: 165-170
DOI: 10.5152/etd.2017.1732
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Key Words: Aspirin, cathepsin B, caspase-3, catalase, Morinda citrifolia (noni), SOD
Abstract

Objective: Isoproterenol (iso)-induced myocardial infarction is a widely used experimental model to study the beneficial effects of many drugs. Morinda citrifolia (noni) has traditionally been used for treating many diseases. Low-dose aspirin may have been protected heart tissueThis study aimed to investigate the possible protective effects of noni (20%) and low-dose aspirin (30 mg/kg) against iso-induced acute myocardial infarction in male Wistar rats.

 

Materials and Methods: Rats were divided into control, iso, iso+noni, iso+aspirin, and iso+aspirin+noni groups (n=8). Myocardial infarction was induced by subcutaneous injection of iso (100 mg/kg) for two consecutive days. Iso-induced rats showed increased serum Creatine kinase- muscle brain CK-MB activity. The effects of noni (20%) and low-dose aspirin (30 mg/kg) were evaluated in response to iso-induced changes, Malondialdehyde (MDA), Superoxide Dismutase (SOD), Catalase (CAT), DNA fragmentation, caspase-3, and cathepsins B and L.

 

Results: Oral treatment with 20% noni juice and low-dose aspirin (30 mg/kg) for 7 days significantly decreased apoptotic markers such as DNA fragmentation, caspase-3, and cathepsins B and L; increased antioxidant enzymes such as SOD and catalase activities; and decreased MDA levels.

 

Conclusion: We propose that the protective effect, antiapoptotic and antioxidant mechanisms of noni and low dose aspirin may be on iso-induced myocardial infarction.

 

Cite this article as: Kuşat Ol K, Kanbak G, Oğlakçı İlhan A, Kartkaya K, Erden İnal M. Morinda Citrifolia (Noni) and Low Dose Aspirin Prevent Apoptotic Cell Death and Oxidative Stress on Isoproterenol Induced Myocardial Infarction in Rats. Erciyes Med J 2017; 39(4): 165-70.

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