ISSN 2149-2247 | E-ISSN 2149-2549
Original Investigation
Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy
1 Department of Thoracic Surgery, Erciyes University Faculty of Medicine, Kayseri, Turkey  
Erciyes Med J 2017; 39: 154-159
DOI: 10.5152/etd.2017.17006
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Key Words: Lymph nodes, non-small cell lung cancer, technetium-99-m methoxy isobutyl isonitrile
Abstract

Objective: The aim of this study is to evaluate the mediastinal lymph node (MLN) metastasis comparatively with Tc99m-MIBI SPECT scintigraphy, thoracic computed tomography (CT), and video-mediastinoscopy (VM) in the staging of non-small cell lung cancer (NSCLC).

 

Materials and Methods: Forty consecutive patients (36 men, 4 women, average age 59.3 years) who were to undergo surgical treatment for NSCLC between June 2008 and June 2009 were included in this prospective study. All patients underwent chest 99mTc-MIBI SPECT before VM. SPECT results were evaluated visually and semi-quantitatively. Thoracotomy and MLN dissection were applied in patients who did not have MLN metastasis.

 

Results: The MLN involvement was demonstrated in 6 patients via VM. 99mTc-MIBI SPECT correctly staged 5 out of 6 patients, and CT 2 out of 6 patients. The 99mTc-MIBI SPECT showed better results than CT with regard to positive and negative predictive values and accuracy.

 

Conclusion: This study indicates that Tc99m-MIBI SPECT has a better diagnostic value than CT in detecting MLN metastases in NSCLC.

 

Cite this article as: Önal Ö, Demir ÖF. Comparative Evaluation of Mediastinal Lymph Nodes in Non-small Cell Lung Cancer with Computed Tomography, 99mTc-MIBI SPECT, and Video-Mediastinoscopy.Erciyes Med J 2017; 39(4): 154-9.

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