ISSN 2149-2247 | E-ISSN 2149-2549
Original Investigation
Evaluation of Index of Cardio-Electrophysiological Balance (iCEB) in Patients with Rheumatoid Arthritis
1 Department of Cardiology, Trakya University Hospital, Edirne, Turkey  
Erciyes Med J ; : -
DOI: 10.5152/etd.2017.17030
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Key Words: Index of cardio-electrophysiological balance, rheumatoid arthritis, sudden cardiac death
Abstract

Objectives: Index of cardioelectrophysiological balance (iCEB), measured as QT interval divided by QRS duration, is defined recently as a new risk marker for arrhythmias. Increased or decreased iCEB is associated with malignant ventricular arrhythmias. We aimed to investigate the ventricular balance between the depolarization (changes in QRS duration) and repolarization (changes in the QT interval) of the cardiac action potential in rheumatoid arthritis (RA) patients by using iCEB.

 

Materials and Methods: Totally 60 patients (mean age was 49.4 ±11.7 years and 61% of the patients were female) with RA and 60 control subjects (45.3 ±12.6 years and 60% of the patients were female) were enrolled. iCEB (QT/QRS) and iCEBc [heart rate-corrected QT(QTc)/QRS] were calculated from the 12-lead electrocardiogram.

 

Results: iCEB and iCEBc were significantly higher in patients with RA than control subjects (p<0.001 and p<0.001, respectively) and they were correlated with high-sensitive C-reactive protein (hs-CRP) levels (r= 0.467, p<0.001 and r=0.479,p<0.001, respectively).

 

Conclusions: Our results indicate that iCEB was increased in patients with RA. It is known that high iCEB is associated with torsade de Pointes (TdP) ventricular tachycardia. The increased frequency of ventricular arrhythmias in RA patients may be TdP related and can be clarified by the new index of balance between depolarization and repolarization (iCEB). 

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