ISSN 2149-2247 | E-ISSN 2149-2549
Original Investigation
Comparative evaluation of mediastinal lymph nodes in non–small cell lung cancer with computed tomography, 99mTc-MIBI SPECT and video- mediastinoscopy
1 Department of Thoracic Surgery, Erciyes University Faculty of Medicine, Kayseri, Turkey  
Erciyes Med J ; : -
DOI: 10.5152/etd.2017.17006
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Key Words: Lymph nodes, non-small cell lung cancer, Technetium-99-m methoxyisobutylisonitrile

Objectives: The aim of this study is to evaluate the mediastinal lymph node (MLN) metastasis comparatively with Tc99m-MIBI SPECT scintigraphy, thorax computed tomography (CT) and video-mediastinoscopy (VM) in the staging of non-small cell lung cancer (NSCLC).


Materials and Methods: Forty consecutive patients (36 male, 4 female, average age 59.3 years) who were candidates of surgical treatment for NSCLC between June 2008 and June 2009, were included in this prospective study. All patients underwent chest 99mTc-MIBI SPECT before VM. SPECT results were evaluated visually and semi quantitatively. Thoracotomy and MLN dissection were applied to the patients who did not have MLN metastasis.


Results: MLN involvement was demonstrated in 6 patients by VM. 99mTc-MIBI SPECT correctly staged 5 of 6 patients and CT correctly staged 2 of 6 patients. 99mTc-MIBI SPECT results were better than those of CT with regard to positive and negative predictive values and accuracy.


Conclusion: This study indicates that Tc99m-MIBI SPECT has a higher diagnostic value than CT in detecting MLN metastasis in NSCLC. 

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